UniProt

Try a search

• What is the function of the protein encoded by EGFR and which diseases is it involved in?
• Map the genes BRAF, KRAS and TP53 to their Ensembl gene IDs
• Which DrugBank drugs target the human HER2 protein?
• What is the ChEMBL target ID for PCSK9?
• Which proteins does DrugBank drug DB00945 (aspirin) target?

Tools (3)

1. getProteinEntryGet a curated UniProtKB entry by accession: function, subcellular location, disease involvement (with OMIM IDs), natural variant summary, DrugBank drugs targeting the protein, and identifiers that chain into other sources (Ensembl gene = Open Targets target ID, NCBI Gene, HGNC, ChEMBL target, OMIM, PDB). Use searchProteins or mapIds first to get the accession from a gene symbol.Free
2. searchProteinsSearch UniProtKB proteins by gene symbol, protein name or free text. Defaults to human, reviewed (Swiss-Prot) entries. Use the returned accessions with getProteinEntry for function, disease, variants, drugs and cross-references, or with mapIds to convert identifiers.Free
3. mapIdsConvert biological identifiers through UniProt: gene symbol <-> UniProt accession <-> Ensembl gene/transcript/protein, NCBI Gene, HGNC, ChEMBL target, DrugBank, PDB, OMIM, RefSeq protein. Mappings between two non-UniProt namespaces (e.g. geneSymbol -> ensemblGene) go through UniProt accessions. Ensembl gene IDs are Open Targets target IDs; ChEMBL target IDs chain into ChEMBL; DrugBank -> uniprot lists a drug's protein targets.Free