# getTargetProfile

**Identifier:** `opentargets_getTargetProfile`

**Provider:** [OpenTargets](https://kirha.com/providers/opentargets.md)

Target druggability and safety profile from Open Targets: tractability by modality (small molecule, antibody, PROTAC, other), known safety liabilities with affected tissues and sources, target class, UniProt ID, essentiality, loss-of-function constraint and high-quality chemical probes. Pass the symbol or uniprotId to chembl-mcp searchTargets to get the ChEMBL target ID for bioactivity data.

## Run it with the CLI

```bash
kirha tools run opentargets_getTargetProfile \
  --input '{
    "targetId": "ENSG00000146648"
  }'
```

`--input` takes a JSON object that matches the input schema. Pass `--input -` to read it from stdin.

## Call it over HTTP

```bash
curl https://api.kirha.com/tools/v1/execute \
  --request POST \
  --header 'Content-Type: application/json' \
  --header 'Authorization: **********' \
  --data '{
  "tool_name": "opentargets_getTargetProfile",
  "input": {
    "targetId": "ENSG00000146648"
  }
}'
```

Replace the stars with an API key from https://app.kirha.com/api-keys.

## Input schema

```json
{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "properties": {
    "targetId": {
      "description": "Ensembl gene ID from searchEntities, e.g. ENSG00000146648",
      "type": "string"
    }
  },
  "required": [
    "targetId"
  ],
  "type": "object"
}
```

## Output schema

```json
{
  "$schema": "https://json-schema.org/draft/2020-12/schema",
  "additionalProperties": false,
  "properties": {
    "biotype": {
      "type": "string"
    },
    "context": {
      "type": "string"
    },
    "function": {
      "type": "string"
    },
    "highQualityChemicalProbes": {
      "description": "Probe name, or name:ChEMBL ID (ChEMBL ID usable in chembl-mcp getBioactivities)",
      "items": {
        "type": "string"
      },
      "type": "array"
    },
    "isEssential": {
      "description": "Core essential gene in DepMap CRISPR screens",
      "type": "boolean"
    },
    "knownDrugCount": {
      "description": "Drugs and clinical candidates, see getKnownDrugs",
      "type": "number"
    },
    "lofObservedExpected": {
      "description": "gnomAD loss-of-function observed/expected; low (<0.35) means LoF-intolerant",
      "type": "number"
    },
    "name": {
      "type": "string"
    },
    "safetyLiabilities": {
      "items": {
        "additionalProperties": false,
        "properties": {
          "effect": {
            "type": "string"
          },
          "event": {
            "type": "string"
          },
          "eventId": {
            "type": "string"
          },
          "pmid": {
            "type": "string"
          },
          "source": {
            "type": "string"
          },
          "tissues": {
            "items": {
              "type": "string"
            },
            "type": "array"
          }
        },
        "required": [
          "event",
          "source"
        ],
        "type": "object"
      },
      "type": "array"
    },
    "symbol": {
      "type": "string"
    },
    "targetClass": {
      "description": "From broadest to most specific",
      "items": {
        "type": "string"
      },
      "type": "array"
    },
    "targetId": {
      "type": "string"
    },
    "tractability": {
      "description": "Only tractability buckets that are true",
      "items": {
        "additionalProperties": false,
        "properties": {
          "evidence": {
            "items": {
              "type": "string"
            },
            "type": "array"
          },
          "modality": {
            "type": "string"
          }
        },
        "required": [
          "modality",
          "evidence"
        ],
        "type": "object"
      },
      "type": "array"
    },
    "uniprotId": {
      "type": "string"
    }
  },
  "required": [
    "context",
    "targetId",
    "tractability",
    "safetyLiabilities"
  ],
  "type": "object"
}
```

## Related tools

Other OpenTargets tools that this tool refers to, or that refer to it.

- [`getDiseaseAssociatedTargets`](https://kirha.com/providers/opentargets/getDiseaseAssociatedTargets.md)
- [`getDrugProfile`](https://kirha.com/providers/opentargets/getDrugProfile.md)
- [`searchEntities`](https://kirha.com/providers/opentargets/searchEntities.md)
- [`getKnownDrugs`](https://kirha.com/providers/opentargets/getKnownDrugs.md)

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