# OpenTargets

This provider exposes tools and data accessible through its parent verticals. Use the example prompts as inspiration for your queries.

**Slug:** `opentargets`

**Description:** Open Targets Platform: target-disease associations with evidence scores, approved drugs and clinical candidates per disease or target, and target tractability and safety. ID links: start with searchEntities (name to Ensembl/EFO/MONDO/ChEMBL ID); drug ChEMBL IDs are shared with chembl-mcp; Ensembl targets bridge to chembl-mcp searchTargets via gene symbol or UniProt ID; NCT IDs feed clinicaltrials-mcp getStudyDetails; PMIDs feed pubmed-mcp fetchPubmedArticles; drug names feed rxnorm-mcp findDrugByName.

## Verticals

This provider is available in the following verticals:

- [Medical](https://kirha.com/verticals/medical.md)

## Example prompts (non-exhaustive)

- `Which targets have the strongest genetic evidence for coronary artery disease?`
- `List approved drugs and phase 3 candidates for non-small cell lung cancer with their mechanisms`
- `Is EGFR tractable with small molecules and antibodies, and what are its known safety liabilities?`
- `Why is PCSK9 associated with coronary artery disease? Show GWAS and clinical evidence`
- `What diseases is imatinib approved or in trials for, and which targets does it hit?`

## Available tools in this provider

Open a tool to see its input and output schemas.

### [`getTargetAssociatedDiseases`](https://kirha.com/providers/opentargets/getTargetAssociatedDiseases.md)

Rank the diseases associated with a target (gene) by Open Targets association score (0-1), with the score broken down per evidence type. Pass diseaseIds to score specific target-disease pairs. Target IDs are Ensembl; use the symbol with chembl-mcp searchTargets for ChEMBL bioactivity data.

### [`getTargetProfile`](https://kirha.com/providers/opentargets/getTargetProfile.md)

Target druggability and safety profile from Open Targets: tractability by modality (small molecule, antibody, PROTAC, other), known safety liabilities with affected tissues and sources, target class, UniProt ID, essentiality, loss-of-function constraint and high-quality chemical probes. Pass the symbol or uniprotId to chembl-mcp searchTargets to get the ChEMBL target ID for bioactivity data.

### [`getDiseaseAssociatedTargets`](https://kirha.com/providers/opentargets/getDiseaseAssociatedTargets.md)

Rank the targets (genes) associated with a disease by Open Targets association score (0-1), with the score broken down per evidence type. Pass targetIds to score specific target-disease pairs. Target IDs are Ensembl; use the symbol with chembl-mcp searchTargets for ChEMBL bioactivity data.

### [`getDrugProfile`](https://kirha.com/providers/opentargets/getDrugProfile.md)

Drug profile from Open Targets by ChEMBL ID: modality, highest clinical stage, mechanisms of action with Ensembl target IDs, withdrawal/black-box warnings, and indications ranked by stage with disease IDs. Bridges a ChEMBL drug (from chembl-mcp or searchEntities) to Ensembl targets and EFO/MONDO diseases; trade names feed rxnorm-mcp findDrugByName.

### [`searchEntities`](https://kirha.com/providers/opentargets/searchEntities.md)

Resolve a gene/protein, disease or drug name (brand names and synonyms included) to Open Targets IDs: Ensembl gene IDs for targets, EFO/MONDO IDs for diseases, ChEMBL IDs for drugs. Use this first; the IDs feed every other Open Targets tool, drug ChEMBL IDs also work in chembl-mcp (getMechanisms, getDrugIndications, getBioactivities, getMolecules). Target IDs here are Ensembl, not ChEMBL target IDs: use the symbol with chembl-mcp searchTargets for those.

### [`getTargetDiseaseEvidence`](https://kirha.com/providers/opentargets/getTargetDiseaseEvidence.md)

Explain why a target is associated with a disease: the direct association score, then the top evidence rows from each contributing datasource (GWAS credible sets, ClinVar/EVA, somatic mutation catalogs, clinical precedence with drug and NCT ID, literature mining with PMIDs...). Use after getTargetAssociatedDiseases or getDiseaseAssociatedTargets. PMIDs feed pubmed-mcp fetchPubmedArticles, NCT IDs feed clinicaltrials-mcp getStudyDetails, drug ChEMBL IDs feed chembl-mcp.

### [`getKnownDrugs`](https://kirha.com/providers/opentargets/getKnownDrugs.md)

List approved drugs and clinical candidates for a disease or for a target (pass exactly one of diseaseId/targetId), with the highest clinical stage reached for that disease/target, mechanism of action, trial status counts and NCT IDs (for clinicaltrials-mcp getStudyDetails). Drug IDs are ChEMBL IDs, usable in chembl-mcp; drug names feed rxnorm-mcp findDrugByName. Ranked by stage; stageCounts summarises the full pipeline before the limit.

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**Tags:** drug-discovery, targets, genetics, diseases, drugs, life-sciences

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